Blood Collection PRP Tube
Short Description:
Blood derived products have demonstrated their capacity to enhance healing and stimulate the regeneration of different tissues and this enhancing effect is attributed to the growth factors and bioactive proteins that are synthesized and present in blood.
Spinal pathologies usually manifest in the form of back pain radiating to the peripheries, sensory and motor loss. All these eventually affect the quality of life and increase the morbidity rate. Studies have supported the use of PRP in the treatment of back pain. The efficacy and safety of PRP as a biological therapy for degenerative spinal conditions are also proven. A study evaluated the effectiveness of PRP in selected participants after confirming disc disease by using magnetic resonance imaging (MRI) and standardized provocative discography. The candidates were given PRP treatment and followed up for ten months. The results showed significant pain improvement without any obvious side effects.
PRP stimulates the injured area and starts the processes of proliferation, recruitment, and differentiation, initiating reparation. Subsequent release of growth factors like VEGF, EGF, TGF-b, and PDGF contributes to improving the integrity of the damaged tissue. The formation of cellular and extracellular matrix supports the destructing intervertebral disc, and thus, mitigates the disease severity
One of the mechanisms of excessive tissue destruction is uncontrolled activation of the inflammatory cascade and an imbalance between inflammatory and counter hormones. The chemokines and cytokines within the platelets stimulate the immunological and inflammatory aspects of healing, while the anti-inflammatory cytokines counter the excessive recruitment of leukocytes. The smooth regulation of chemokines prevents excessive inflammation, increasing the healing and decreasing the damage.
Disc degeneration is a complex process. It can be due to aging, vascular insufficiency, apoptosis, diminished nutrients to the disc cells, and genetic factors. The avascular nature of the disc interferes with the healing of the tissue. Further, the inflammation-mediated changes occur in both nucleus pulposus and inner annulus fibrosus. This causes the disc cells to release a large number of pro-inflammatory cytokines amplifying the destruction. Injection of PRP directly into the affected disc allows the healing to occur smoothly.
